Why the study?
Does bretylium reduce the incidence of ventricular fibrillation during coronary reperfusion in a canine model?
Population
50 dogs subjected to 20 min proximal left anterior descending coronary artery ligation followed by sudden…
Comparison
Bretylium tosylate 10 mg/kg infusion over 10… vs Saline placebo
Design
Preclinical
Follow-up
during reperfusion
Authors
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Hypothesis-generating for bretylium in reperfusion VF; prospective human trials needed before clinical adoption.
Does bretylium reduce the incidence of ventricular fibrillation during coronary reperfusion in a canine model?
Bretylium significantly reduces the likelihood of ventricular fibrillation during coronary reperfusion in a canine model when controlling for the amount of myocardium at risk.
Wenger et al. (1984) studied this question.
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