Why the study?
Does bretylium or lidocaine prevent ventricular fibrillation in isolated rabbit hearts lacking an intact sympathetic nervous system?
Population
Isolated, perfused rabbit hearts
Design
Preclinical
Authors
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Lidocaine may exert direct antifibrillatory effects independent of sympathetic input; leaves open bretylium efficacy and clinical translation.
Does bretylium or lidocaine prevent ventricular fibrillation in isolated rabbit hearts lacking an intact sympathetic nervous system?
Lidocaine exerts direct cellular antifibrillatory effects, whereas bretylium requires an intact sympathetic nervous system for its antifibrillatory action.
Aravindakshan et al. (1975) studied this question.
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