Key result
Pretreatment with nortriptyline attenuated and delayed the acute antifibrillatory effect of bretylium, with ventricular fibrillation threshold reaching 25.2 mA at 90 min compared to 45.1 mA with saline.
Why the study?
Does pretreatment with nortriptyline attenuate the antifibrillatory effect of bretylium in pentobarbital anesthetized dogs?
Population
Pentobarbital anesthetized dogs (n=17)
Comparison
Nortriptyline 3 mg/kg followed by bretylium 5… vs Saline followed by bretylium 5 mg/kg intravenously
Design
Preclinical
Follow-up
90 minutes
Authors
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Alerts to potential nortriptyline-bretylium interaction in VF-prone patients; leaves open translation of adrenergic mechanism to humans.
Does pretreatment with nortriptyline attenuate the antifibrillatory effect of bretylium in pentobarbital anesthetized dogs?
p-value: p=<0.05
Pretreatment with nortriptyline attenuates and delays the acute antifibrillatory effect of bretylium, suggesting that cardiac adrenergic neurons are a key target for its beneficial effects.
Kopia et al. (2008) studied Ventricular fibrillation (n=17). Nortriptyline pretreatment followed by bretylium vs. Saline pretreatment followed by bretylium was evaluated on Electrical ventricular fibrillation threshold (VFT) (p=<0.05). Pretreatment with nortriptyline attenuated and delayed the acute antifibrillatory effect of bretylium, with ventricular fibrillation threshold reaching 25.2 mA at 90 min compared to 45.1 mA with saline.
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