Key result
Long-term administration of olmesartan induced marked proliferative changes in afferent arteriolar smooth muscle cells in Zucker fatty rats (77.3% vs 1.7% in controls; p<0.005).
Why the study?
Does olmesartan induce morphological changes in renal afferent arterioles in Zucker fatty rats?
Population
32 6-week-old male Zucker fatty rats (ZFRs)
Comparison
Olmesartan 5 mg/kg/day added to standard or… vs Standard or high-salt diet without ARB
Design
Preclinical
Authors
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May signal arteriolar damage risk with chronic olmesartan in obese diabetic models; leaves open human relevance and need for prospective study.
Does olmesartan induce morphological changes in renal afferent arterioles in Zucker fatty rats?
Absolute Event Rate: 77.3% vs 1.7%
p-value: p=< 0.005
Long-term olmesartan administration in Zucker fatty rats induces unusual proliferative changes in afferent arteriolar smooth muscle cells, which may reduce intraglomerular pressure but potentially cause irreversible arteriolar damage.
Nakanishi et al. (2011) studied Zucker fatty rats (animal model) (n=32). Olmesartan (ARB) vs. No ARB (standard or high-salt diet alone) was evaluated on Proliferative changes in the afferent arteriolar smooth muscle cells (SMCs) (p=< 0.005). Long-term administration of olmesartan induced marked proliferative changes in afferent arteriolar smooth muscle cells in Zucker fatty rats (77.3% vs 1.7% in controls; p<0.005).
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