What question did this study set out to answer?

To evaluate the morphological and proliferative alterations in renal afferent arteriolar walls associated with angiotensin II type 1 receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI) therapy in humans.

January 1, 2020Kidney & Blood Pressure ResearchOpen Access

A Study of Morphological Changes in Renal Afferent Arterioles Induced by Angiotensin II Type 1 Receptor Blockers in Hypertensive Patients

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Authors

YNYohko NagaiToho University FYFumito YamabeToho University YSYosuke SasakiShowa University

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Implication

Retrospective comparative study reveals marked afferent arteriolar narrowing in hypertensive patients receiving ARBs or ACEIs, suggesting potential risk of glomerular ischemia.

Key Points

To evaluate the morphological and proliferative alterations in renal afferent arteriolar walls associated with angiotensin II type 1 receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACEI) therapy in humans.
Analyzed 44 renal wedge resection specimens obtained from 92 nephrectomized kidneys of patients aged 45–74 years resected for malignancy between 2013 and 2016.
Categorized patients into three groups: hypertensive treated with ARBs/ACEIs (HTARB, n=18), hypertensive treated with calcium channel blockers without ARBs/ACEIs (HTCCB, n=6), and normotensive controls (n=20), excluding conditions with known vascular changes like diabetes.
Quantified the inner-to-outer arteriolar diameter ratio and utilized blinded pathologist scoring to evaluate smooth muscle cell proliferation, arrangement irregularity, and cell size.
The inner/outer arteriolar diameter ratio was significantly lower in the HTARB group (0.39 ± 0.05) compared to the HTCCB group (0.46 ± 0.02, p = 0.0107) and the normotensive control group (0.53 ± 0.02, p = 0.00001).
The arteriolar diameter ratio positively correlated with estimated glomerular filtration rate across all three cohorts (r = 0.4915, p < 0.0007).
Afferent arteriolar smooth muscle cell abnormality scores for proliferation, irregular arrangement, and size were significantly elevated in the HTARB group compared to the other two cohorts (p = 0.0088, p = 0.00001, and p = 0.025, respectively).

Cite This Study

Nagai et al. (2020) studied this question.

synapsesocial.com/papers/6a97ca5190d51c6c12faddac https://doi.org/10.1159/000505025

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Implication

Retrospective comparative study reveals marked afferent arteriolar narrowing in hypertensive patients receiving ARBs or ACEIs, suggesting potential risk of glomerular ischemia.

A Study of Morphological Changes in Renal Afferent Arterioles Induced by Angiotensin II Type 1 Receptor Blockers in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

A Study of Morphological Changes in Renal Afferent Arterioles Induced by Angiotensin II Type 1 Receptor Blockers in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Cite This Study

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