Why the study?
Does long-term administration of enalapril induce morphological changes in renal afferent arterioles in Zucker fatty rats?
Population
14 6-week-old male Zucker fatty rats (ZFRs)
Comparison
Enalapril 2 mg/kg/day administered via standard… vs Standard diet without ACE inhibitor for 12 weeks
Design
Preclinical
Follow-up
12 weeks
Authors
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May signal risk of irreversible arteriolar damage with chronic ACEI in obese models; leaves open human relevance and net renal effects.
Does long-term administration of enalapril induce morphological changes in renal afferent arterioles in Zucker fatty rats?
Long-term enalapril administration in Zucker fatty rats induces significant proliferative changes in renal afferent arteriolar smooth muscle cells, which may cause irreversible arteriolar damage despite potentially reducing intraglomerular pressure.
Nakanishi et al. (2017) studied this question.
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