April 1, 1981AJP Heart and Circulatory Physiology
Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations
Key result
Cardiac contractility strongly correlated with Ca2+ binding to isolated cardiac sarcolemma in rabbit, neonatal rat, and frog ventricular tissue, but deviated in adult rat ventricle and rabbit atrium.
Population
Isolated cardiac sarcolemma from rabbit, neonatal rat, and frog ventricular tissue, as well as adult rat…
Design
Preclinical
Authors
Discussion
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Implication
Animal findings should not guide human therapy; leaves open sarcolemmal Ca2+ contribution to contractility in patients.
Structured PICO
P
Population
Isolated cardiac sarcolemma from rabbit, neonatal rat, and frog ventricular tissue, as well as adult rat ventricle and rabbit atrium
E
Exposure
Various ionic conditions to assess Ca2+ binding
O
Outcome
Correlation between cardiac contractility and Ca2+ binding to isolated cardiac sarcolemmasurrogate
This preclinical study suggests that Ca2+ bound to the cardiac sarcolemma plays a major role in controlling myocardial contractility, with varying dependence on sarcolemmal Ca2+ entry versus sarcoplasmic reticulum Ca2+ release across different species and tissues.
Cite This Study
Bers et al. (1981) studied this question. Ca2+ binding to isolated cardiac sarcolemma was evaluated on Correlation between cardiac contractility and Ca2+ binding. Cardiac contractility strongly correlated with Ca2+ binding to isolated cardiac sarcolemma in rabbit, neonatal rat, and frog ventricular tissue, but deviated in adult rat ventricle and rabbit atrium.