January 1, 1989Thrombosis and Haemostasis
Additive Effect of dDAVP and Standard Heparin inIncreasing Plasma t-PA
Key result
dDAVP followed by standard heparin significantly increased plasma t-PA activity and antigen compared to dDAVP followed by saline, demonstrating an additive effect on endogenous fibrinolysis.
Why the study?
Does dDAVP combined with standard heparin increase plasma t-PA compared to dDAVP combined with saline in healthy volunteers?
Population
8 healthy volunteers
Comparison
dDAVP 0.4 micrograms/kg i.v. over 15 minutes… vs dDAVP 0.4 micrograms/kg i.v. over 15 minutes…
Design
RCT, randomized cross-over, double blind placebo controlled
Follow-up
up to 60 minutes after infusion
Authors
Discussion
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Implication
Supports testing dDAVP-heparin for thromboembolic prophylaxis; extends RCT evidence of additive fibrinolysis from healthy volunteers.
Study Design
Type
RCT (n=8)
Blinding
Double-blind
Randomization
Cross-over
Structured PICO
Does dDAVP combined with standard heparin increase plasma t-PA compared to dDAVP combined with saline in healthy volunteers?
P
Population
8 healthy volunteers evaluated in a randomized cross-over trial with a 48-hour wash-out period.
I
Intervention
dDAVP 0.4 micrograms/kg i.v. over 15 minutes followed by an i.v. bolus dose of standard heparin 5,000 I.U.
C
Comparator
dDAVP 0.4 micrograms/kg i.v. over 15 minutes followed by an i.v. bolus dose of saline
O
Outcome
Plasma t-PA activity and t-PA antigensurrogate
The combination of dDAVP and standard heparin has an additive effect on increasing circulating t-PA, suggesting potential utility in the prophylaxis and treatment of thromboembolic diseases.
Cite This Study
Agnelli et al. (1989) conducted an RCT in Healthy volunteers (n=8). dDAVP and standard heparin vs. dDAVP followed by saline was evaluated on Plasma t-PA activity, t-PA antigen, circulating t-PA specific activity and FPLA. dDAVP followed by standard heparin significantly increased plasma t-PA activity and antigen compared to dDAVP followed by saline, demonstrating an additive effect on endogenous fibrinolysis.