Key result
Universal mass vaccination with Rotarix appears to enrich RVA strains with the G2P[4] genotype, whereas RotaTeq coverage is associated with an unexplained G3P[8] genotype increase.
Why the study?
Does universal mass vaccination influence the prevalence of rotavirus genotypes?
Population
Populations in regions with universal mass vaccination programs for group A rotavirus
Design
Review
Authors
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Strain surveillance remains essential after rotavirus vaccination; leaves open whether genotype shifts affect long-term effectiveness.
Does universal mass vaccination influence the prevalence of rotavirus genotypes?
Universal mass vaccination with rotavirus vaccines may exert selective pressure leading to the enrichment of specific rotavirus genotypes, though some observed shifts remain unexplained by current theoretical models.
Matthijnssens et al. (2012) conducted a review in Group A rotavirus (RVA) infection. Group A rotavirus universal mass vaccination was evaluated on RVA genotype distribution. Universal mass vaccination with Rotarix appears to enrich RVA strains with the G2P[4] genotype, whereas RotaTeq coverage is associated with an unexplained G3P[8] genotype increase.
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