Key result
In pregnant and lactating goats, acute NaCl loading increased plasma ANP levels significantly, but the natriuretic response to ANP appeared attenuated compared to the nonpregnant state.
Why the study?
Does acute NaCl loading or ANP infusion affect natriuresis in pregnant and lactating goats?
Does acute NaCl loading or ANP infusion affect natriuresis in pregnant and lactating goats?
The natriuretic response to atrial natriuretic peptide appears attenuated during pregnancy and lactation in goats.
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Attenuated ANP natriuresis in pregnant goats should not inform human care; leaves open whether similar resistance occurs in human pregnancy.
Olsson et al. (1989) studied Pregnancy and lactation (n=6). Rapid iv load of 0.9% NaCl and iv infusions of ANP vs. Nonpregnant, nonlactating control period was evaluated on Plasma ANP concentrations and renal Na excretion. In pregnant and lactating goats, acute NaCl loading increased plasma ANP levels significantly, but the natriuretic response to ANP appeared attenuated compared to the nonpregnant state.
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