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September 2, 2026BMC NephrologyOpen Access

Acute peritoneal dialysis adequacy among children at a national referral hospital in Kenya: a cross-sectional study in a resource-limited setting

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Authors

DNDoreen NgangaBABashir AdmaniD(Dalton Wamalwa (3661483)

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Overview

Cross-sectional study demonstrates significant solute clearance with acute peritoneal dialysis in pediatric kidney injury, indicating effective short-term biochemical control in resource-limited...

Key Points

  • To assess acute peritoneal dialysis adequacy and describe urea and creatinine clearance in pediatric patients with acute kidney injury at a national referral hospital.
  • Enrolled 64 children initiating acute peritoneal dialysis over a 5-month period at Kenyatta National Hospital in Nairobi, Kenya.
  • Recorded drain volumes, dialysate dextrose concentrations, and serum and effluent solute levels before and after 24 hours of dialysis to calculate daily urea and creatinine clearance.
  • Evaluated solute changes using paired t-tests and performed descriptive analyses across dialysate dextrose concentration groups.
  • Among 64 enrolled children (median age 18 days; 43% female), median daily creatinine clearance was 5.13 L/day/1.73 m² and median daily urea clearance was 1.03.
  • Mean serum urea and creatinine concentrations decreased significantly after the first 24 hours of dialysis.
  • Sick neonates demonstrated the highest risk of developing acute kidney injury relative to older pediatric age groups.

Cite This Study

Nganga et al. (2026) studied this question.

synapsesocial.com/papers/6a97e20ec562ede874ec6271https://doi.org/10.1186/s12882-026-05338-6
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Also Consider

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  1. 1Clinical Profile and Survival Outcomes of Children with Acute Kidney Injury Requiring Renal Replacement Therapy: A Retrospective Study from a Tertiary Pediatric Intensive Care Unit2026
  2. 2Are Both Creatinine and Urea Clearances Necessary as Indices of Small Solute Clearance Adequacy in Peritoneal Dialysis?2000
  3. 3Acute Peritoneal Dialysis in Critical Preterm Infants: A Case Series and Review of the Literature2025
  4. 4Solute clearance measurement in the assessment of dialysis adequacy among African continuous ambulatory peritoneal dialysis patients2015
  5. 5Incidence and Factors Associated with Peritoneal Dialysis-Related Peritonitis in Children2024