Key result
Prenatal risk factors including family history of CHD, major extra-cardiac anomalies, maternal smoking, and maternal medication exposure were associated with increased odds of CHD (P<0.05 for all).
Why the study?
What prenatal risk factors are associated with the development of congenital heart disease?
Population
Children <18 years old with congenital heart disease and controls without structural heart disease…
Design
Case-control
Authors
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May inform prenatal counseling on modifiable risks; leaves open prospective validation of these associations.
Case-Control (n=2,538)
Yes
What prenatal risk factors are associated with the development of congenital heart disease?
p-value: p=<0.05
Maternal smoking, medication exposure, and advanced parental age are increasingly prevalent prenatal risk factors associated with higher odds of congenital heart disease.
Fung et al. (2013) conducted a case-control in Congenital heart disease (n=2,538). Prenatal risk factors (e.g., family history, maternal smoking, medication exposure) vs. Absence of risk factors / Controls without structural heart disease was evaluated on Congenital heart disease (p=<0.05). Prenatal risk factors including family history of CHD, major extra-cardiac anomalies, maternal smoking, and maternal medication exposure were associated with increased odds of CHD (P<0.05 for all).
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