Key result
Every 5% decrease in flow-mediated dilation was associated with a 7.5 mmHg decrease in SBP (P=0.02), and every 5 m/s increase in pulse wave velocity with an 8 mmHg increase in SBP (P=0.03).
Why the study?
Are endothelial dysfunction and arterial stiffness associated with intradialytic hypotension and hypertension in hemodialysis patients?
Population
30 patients with end-stage renal disease on chronic hemodialysis
Design
Cross-sectional
Follow-up
1 month
Authors
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Endothelial dysfunction and stiffness may contribute to intradialytic BP instability; leaves open whether modifying them alters hemodialysis outcomes.
Cross-Sectional (n=30)
Yes
Are endothelial dysfunction and arterial stiffness associated with intradialytic hypotension and hypertension in hemodialysis patients?
p-value: p=0.02
Endothelial dysfunction and arterial stiffness are independently associated with intradialytic hypotension and hypertension, respectively, suggesting potential mechanisms for hemodynamic instability during dialysis.
Dubin et al. (2011) conducted a cross-sectional in End-stage renal disease on hemodialysis (n=30). Endothelial dysfunction and arterial stiffness was evaluated on Intradialytic hypotension and hypertension (average decrease in systolic blood pressure over 1 week, and frequency over 1 month) (p=0.02). Every 5% decrease in flow-mediated dilation was associated with a 7.5 mmHg decrease in SBP (P=0.02), and every 5 m/s increase in pulse wave velocity with an 8 mmHg increase in SBP (P=0.03).
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