Key result
Six months of resistance training significantly reduced blood pressure, ATP, and TXB2 levels, and purinergic enzyme activities in hypertensive women to levels similar to normotensive women.
Why the study?
Hypertension is linked to platelet activation and vascular complications, while exercise has antiaggregant effects and can modulate the purinergic system. The study evaluated the effects of 6 months of resistance training on purinergic system components and platelet activation in hypertensive women.
Does 6 months of resistance training reduce platelet activation and modulate purinergic signaling in hypertensive middle-aged women?
Does 6 months of resistance training reduce platelet activation and modulate purinergic signaling in hypertensive middle-aged women?
Six months of resistance training reduces platelet activation and modulates purinergic signaling in hypertensive women, suggesting an antiaggregant benefit of exercise.
May support adjunctive resistance training in hypertensive women; hypothesis-generating and requires randomized confirmation before practice change.
BACKGROUND AND AIM: Essential arterial hypertension is a risk factor for stroke, myocardial infarction, heart failure, and arterial aneurysm, which are related to the activation of platelets. Purinergic signaling has a central role in platelet aggregation. Although ATP and ADP can act as a proaggregant agent, adenosine inhibits platelet aggregation and reduces vascular injury. Physical exercise exhibits antiaggregant properties and can modulate purinergic system. The aim of this study was to evaluate the effect of 6 months of resistance training on purinergic system components in platelets and on platelet activation, hemodynamic and anthropometric parameters in hypertensive woman. METHOD: A total of 31 hypertensive and 28 normotensive middle-aged sedentary women were submitted to 6 months of resistance training. Purinergic enzymes activities were assessed in platelets; ATP and Tromboxane B2 (TXB2) levels were measured in serum. Blood pressure (BP), BMI, and body fat were also measured. All variables were statistically analyzed, considering P value less than 0.05. RESULTS: Six months of resistance training was able to significantly reduce BP, ATP, and TXB2 levels as well as NTPDase, ecto-5'nucleotidase, and ADA activities in hypertensive group. After 6 months of resistance training, purinergic system components and TXB2 of hypertensive group were similar to normotensive group in platelets, demonstrating that resistance training was able to modulate platelet activation. A positive correlation was found between BP, enzyme activities, and levels of ATP and TXB2. CONCLUSION: Our findings demonstrated the relationship between purinergic signaling and platelet activation in hypertension and suggests that resistance training serve as tool to reduce platelet aggregation in hypertensive woman by modulating purinergic system.
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Cardoso et al. (2023) studied Essential arterial hypertension (n=59). Resistance training vs. Normotensive women / Baseline was evaluated on Purinergic enzymes activities, ATP and TXB2 levels, blood pressure, BMI, and body fat. Six months of resistance training significantly reduced blood pressure, ATP, and TXB2 levels, and purinergic enzyme activities in hypertensive women to levels similar to normotensive women.
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