Why the study?
Does the development of obesity via a high fat diet alter cardiovascular hemodynamics and exercise capacity in dogs?
Does the development of obesity via a high fat diet alter cardiovascular hemodynamics and exercise capacity in dogs?
The rapid development of obesity in a canine model induces early abnormal left ventricular function, characterized by dramatic increases in left atrial pressure during exertion and reduced exercise capacity.
Obesity rapidly impairs exercise hemodynamics in dogs; hypothesis-generating for human obesity-related HFpEF, requires clinical validation.
This study examined the control of cardiovascular dynamics in response to exercise during the development of obesity in dogs. Left atrial pressure (LAP), mean arterial pressure, and cardiac output (CO) were determined both at rest and in response to treadmill exercise (5.6 km/h, 10% grade) first during a control, lean state and then, once a week while the dogs were maintained on a high fat diet (HFD) for 4 weeks. Body weight increased from 22.8 +/- 1.1 to 33.1 +/- 2.0 kg after 4 weeks of HFD. The dogs developed mild hypertension with increases in resting CO, heart rate, and LAP. The response to exercise was characterized by a decrease in LAP when the dogs were lean and, in contrast, by a dramatic increase in LAP during the development of obesity. In addition, after the third week, the dogs could no longer maintain exercise at the original level. These results suggest that abnormal left ventricular function may occur very early during the development of canine obesity.
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Mizelle et al. (1994) studied this question.
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