What question did this study set out to answer?

To determine the nature and time course of autonomic nervous system adaptations during 21 weeks of ad libitum high-fat diet-induced obesity and hypertension.

August 1, 1999Journal of Hypertension

Changes in short-term variability of blood pressure and heart rate during the development of obesity-associated hypertension in high-fat fed dogs

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Authors

PVPatrick VerwaerdeInserm JSJean‐Michel SénardInserm MGMichel GalinierHeart Failure & Transplant

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Implication

HFD-induced BP and HR rises in dogs may signal early autonomic shifts in obesity; leaves open human translation and causality.

Key Points

To determine the nature and time course of autonomic nervous system adaptations during 21 weeks of ad libitum high-fat diet-induced obesity and hypertension.
Fed canine models an ad libitum high-fat diet over a 21-week period.
Assessed body weight, body circumference, metabolic parameters (insulin, free fatty acids), and cardiovascular structure (cardiac output, left ventricular mass).
Evaluated autonomic balance using spectral analysis of systolic blood pressure and heart rate variability, spontaneous baroreflex efficiency, and plasma noradrenaline levels.
The high-fat diet increased body weight by +22.0±2.8%, systolic blood pressure by +23±6%, diastolic blood pressure by +28±5%, heart rate by +19±9%, cardiac output by +22.3±7.7%, and left ventricular mass by +18.1±5.0%, while spontaneous baroreflex efficiency decreased by -55±6%.
Between weeks 1 and 8 of weight gain, systolic blood pressure variability in the low-frequency band and plasma noradrenaline transiently rose in correlation with free fatty acids, accompanied by a sustained decline in heart rate variability in the high-frequency band.
The steady-state phase of obesity-related hypertension was marked by a persistent reduction in the high-frequency band of heart rate variability without elevated noradrenaline levels.

Cite This Study

Verwaerde et al. (1999) studied this question.

synapsesocial.com/papers/6a8540cef76e40547ac2afd8 https://doi.org/10.1097/00004872-199917080-00013

Topics

Hypertension management Echocardiography

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Changes in short-term variability of blood pressure and heart rate during the development of obesity-associated hypertension in high-fat fed dogs

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Implication

Key Points

Cite This Study

Topics

Changes in short-term variability of blood pressure and heart rate during the development of obesity-associated hypertension in high-fat fed dogs

Discussion

Member takes

Implication

Key Points

Cite This Study

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