Key result
Oral glucose ingestion impaired skeletal muscle microvascular blood flow (0.5-fold from baseline) whereas intravenous glucose infusion increased it (1.3-fold from baseline, P = 0.0006).
Why the study?
It was unclear whether the route of glucose administration influences muscle microvascular blood flow and which gut-derived hormones explain potential divergent responses.
Does oral glucose administration compared to intravenous glucose administration alter skeletal muscle microvascular blood flow in healthy individuals?
Does oral glucose administration compared to intravenous glucose administration alter skeletal muscle microvascular blood flow in healthy individuals?
Absolute Event Rate: 0.5% vs 1.3%
p-value: p=0.0006
Oral glucose ingestion impairs skeletal muscle microvascular blood flow compared to intravenous infusion, an effect potentially mediated by incretins such as GIP.
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May require route-specific protocols in microvascular studies; leaves open gut hormone roles in insulin resistance.
A 2022 study studied Healthy (n=10). Oral glucose tolerance test (OGTT) vs. Intravenous glucose tolerance test (IVGTT) was evaluated on Skeletal muscle microvascular blood flow (MBF) change from baseline (p=0.0006). Oral glucose ingestion impaired skeletal muscle microvascular blood flow (0.5-fold from baseline) whereas intravenous glucose infusion increased it (1.3-fold from baseline, P = 0.0006).