Key result
Premedication with oral clonidine at 2 or 4 mcg/kg significantly reduced the required induction dose of intravenous thiamylal compared to placebo (4.5 and 3.4 vs 5.4 mg/kg, respectively; P<0.05).
Why the study?
Does oral clonidine reduce the dose of thiamylal required to induce anesthesia in children?
Population
60 children (ASA grades I-II, 7-12 yr old)
Comparison
Oral clonidine 2 micrograms/kg or 4… vs Placebo given 105 min before the induction of…
Design
RCT, randomly assigned, double-blind
Follow-up
5 minutes after induction
Authors
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Supports clonidine premedication to reduce thiamylal induction doses in children; extends alpha-2 agonist evidence in pediatric anesthesia.
RCT (n=60)
double-blind
randomly assigned
Does oral clonidine reduce the dose of thiamylal required to induce anesthesia in children?
Absolute Event Rate: 3.4% vs 5.4%
p-value: p=<0.05
Premedication with oral clonidine significantly reduces the dose of intravenous thiamylal required for the induction of anesthesia in children without causing significant hemodynamic changes.
Nishina et al. (1994) conducted an RCT in Children requiring anesthesia induction (n=60). Clonidine vs. Placebo was evaluated on Induction dose of thiamylal (mg/kg) (p=<0.05). Premedication with oral clonidine at 2 or 4 mcg/kg significantly reduced the required induction dose of intravenous thiamylal compared to placebo (4.5 and 3.4 vs 5.4 mg/kg, respectively; P<0.05).
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