Key result
Hypertension in chronic kidney disease is characterized by abnormal circadian rhythms such as non-dipping and nocturnal hypertension, increased blood pressure variability, and treatment resistance.
In patients with CKD, hypertension often presents with abnormal circadian rhythms and treatment resistance, highlighting the importance of out-of-office blood pressure monitoring such as ABPM and home measurements.
慢性腎臓病（chronic kidney disease：CKD）における高血圧のパターンは夜間高血圧，dippingの消失，仮面高血圧といった血圧日内変動の異常，血圧変動性の亢進が特徴であり，自由行動下血圧測定（ambulatory blood pressure monitoring：ABPM）による24時間血圧測定や家庭血圧測定が重要である．さらに，治療抵抗性であり，その原因として塩分貯留，レニン・アンジオテンシン・アルドステロン系の亢進のみならず，交感神経活性の亢進，血管内皮機能障害，血管構造異常といった機序も関与する．
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Shu Wakino (2016) conducted a review in Chronic Kidney Disease and Hypertension. Hypertension in chronic kidney disease is characterized by abnormal circadian rhythms such as non-dipping and nocturnal hypertension, increased blood pressure variability, and treatment resistance.
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