Key result
Lower overall values of regional cerebral oxygen saturation during surgery were significantly associated with postoperative cognitive dysfunction (MD -1.98; 95% CI -3.30 to -0.66; P=0.003).
Why the study?
Postoperative cognitive dysfunction and neurologic deficit remain important adverse outcomes affecting patients, prompting this systematic review to examine the relationship between regional cerebral oxygen saturation and early POCD.
Is lower intraoperative regional cerebral oxygen saturation (rSO2) associated with early postoperative cognitive dysfunction in postoperative patients?
Meta-Analysis (n=532)
Is lower intraoperative regional cerebral oxygen saturation (rSO2) associated with early postoperative cognitive dysfunction in postoperative patients?
Mean Difference: -1.98 (95% CI -3.3–-0.66)
p-value: p=0.003
Lower intraoperative regional cerebral oxygen saturation is significantly associated with the development of early postoperative cognitive dysfunction.
May aid intraoperative risk stratification; leaves open whether rSO2 optimization prevents cognitive dysfunction.
Objective: Postoperative cognitive dysfunction (POCD) and neurologic deficit continues to be an important neuropsychological adverse affecting patients' outcome. We conducted this systematic review to investigate the relationship between regional cerebral oxygen saturation (rSO2) and early POCD in postoperative patients. Materials and Methods: Our search included MEDLINE (PubMed) and Cochrane library, from inception to October 31, 2018. We included studies reporting values of rSO2 at the beginning of and/or during surgery, and the primary outcome was POCD, and excluded articles who do not put postoperative cognitive function as the main observation. Two reviewers assessed the quality of the included articles using the Newcastle-Ottawa Scale and extracted the data. Results: Seven prospective cohort studies that included 532 patients incorporate into this systematic review. About 37.78% (201/532) patients achieved POCD. POCD was associated with significantly lower overall values of rSO2 during surgery compared to the population that did not achieve POCD (mean difference [MD] −1.98; 95% confidence interval [CI] −3.30 to −0.66; P = 0.003). In the subgroup, the lowest rSO2 values intraoperative period were a better predictor of POCD (MD −2.91; 95% CI −4.37 to − 1.46; P
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Feng et al. (2020) conducted a meta-analysis in Postoperative cognitive dysfunction (n=532). Regional cerebral oxygen saturation (rSO2) was evaluated on Postoperative cognitive dysfunction (POCD) (MD -1.98, 95% CI -3.30 to -0.66, p=0.003). Lower overall values of regional cerebral oxygen saturation during surgery were significantly associated with postoperative cognitive dysfunction (MD -1.98; 95% CI -3.30 to -0.66; P=0.003).
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