Why the study?
Are plasma volume and Evans Blue disappearance rate altered in subjects with essential hypertension compared to normotensive subjects?
Are plasma volume and Evans Blue disappearance rate altered in subjects with essential hypertension compared to normotensive subjects?
Essential hypertension is associated with decreased plasma volume and a faster disappearance rate of Evans Blue, suggesting capillary or mixing abnormalities.
Answers are grounded in this paper and cite their sources.
Associated plasma volume reduction in hypertension should not change practice; leaves open capillary or mixing defects for prospective study.
The disappearance rate of intravenously injected Evans Blue, plasma volume, cardiac output, and blood pressure were measured in seven normotensive and eighteen hypertensive subjects. 2. Plasma volume was found to be negatively correlated with the mean arterial pressure, Evans Blue disappearance rate and packed cell volume. 3. Faster disappearance rate of Evans Blue in hypertensive subjects may be due to an abnormality of mixing of the label or of the capillaries.
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Miloš Ulrych (1973) studied this question.
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