Rapid dextran infusion in essential hypertension.
Why the study?
How do hemodynamic responses to rapid dextran infusion differ between men with essential hypertension and normotensive controls?
Population
34 men, including 17 patients with sustained essential hypertension and 17 normotensive controls
Comparison
Rapid dextran infusion vs Normotensive controls receiving the same infusion
Design
Other
Authors
Discussion
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Member takes
Implication
Suggests reduced vascular compliance in hypertension; leaves open effects on clinical volume management.
Structured PICO
How do hemodynamic responses to rapid dextran infusion differ between men with essential hypertension and normotensive controls?
P
Population
34 men, including 17 patients with sustained essential hypertension and 17 normotensive controls
I
Intervention
Rapid dextran infusion
C
Comparator
Normotensive controls receiving the same infusion
O
Outcome
Changes in hemodynamic parameters (central venous pressure, cardiac output, and stroke volume)surrogate
Patients with essential hypertension show a steeper relationship between cardiac output and blood volume during volume expansion, likely due to reduced vascular compliance.
Cite This Study
Safar et al. (1979) studied this question.