Why the study?
Does adjuvant chemotherapy improve disease-free survival in patients with malignant fibrous histiocytoma of the femur and tibia treated by excision?
Does adjuvant chemotherapy improve disease-free survival in patients with malignant fibrous histiocytoma of the femur and tibia treated by excision?
Adjuvant chemotherapy combined with excision appears to substantially improve disease-free survival in patients with malignant fibrous histiocytoma of the femur and tibia compared to excision alone.
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Adjuvant chemotherapy was associated with higher disease-free survival; hypothesis-generating and requires randomized confirmation.
Between 1974 and 1982, twelve patients with malignant fibrous histiocytoma of the femur and tibia were treated by excision and adjuvant chemotherapy. During the same time-period, eighteen patients were treated by excision alone. The disease-free survival rate among the former was 59 per cent (seven of twelve). There was only one survival in the latter group.
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Bacci et al. (1985) studied this question.
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