Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2005Journal of Cerebral Blood Flow & Metabolism

FK419 reduced neurological deficits and ischemic brain damage and restored regional cerebral blood flow, whereas tirofiban did not, despite both improving MCA patency.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does FK419 improve outcomes compared to tirofiban in a guinea-pig model of middle cerebral artery thrombotic occlusion?

Population

Guinea-pigs with photochemically induced middle cerebral artery occlusion, and in vitro platelet/neutrophil…

Comparison

FK419 vs Tirofiban

Design

Preclinical

Authors

AMAkira MoriguchiMMMasashi MaedaKMKayoko Mihara

Discussion

Loading...

Member takes

Overview

Preclinical data warrant human trials of FK419; leaves open translation of microcirculatory benefits to clinical stroke outcomes.

Structured PICO

Does FK419 improve outcomes compared to tirofiban in a guinea-pig model of middle cerebral artery thrombotic occlusion?

P
Population
Guinea-pigs with photochemically induced middle cerebral artery (MCA) occlusion, and in vitro platelet/neutrophil assays
I
Intervention
FK419 (novel nonpeptide platelet glycoprotein IIb/IIIa antagonist)
C
Comparator
Tirofiban
O
Outcome
MCA patency, neurological deficits, ischemic brain damage, and regional cerebral blood flowsurrogate

FK419, unlike tirofiban, ameliorates ischemic brain damage and restores microcirculation in a guinea-pig stroke model, suggesting potential as a treatment for ischemic stroke.

Cite This Study

Moriguchi et al. (2005) studied this question.

synapsesocial.com/papers/6a982ca590d51c6c12fafabbhttps://doi.org/10.1038/sj.jcbfm.9600009
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FK419, a Nonpeptide Platelet Glycoprotein IIb/IIIa Antagonist, Ameliorates Brain Infarction Associated with Thrombotic Focal Cerebral Ischemia in Monkeys: Comparison with Tissue Plasminogen Activator2005 · 21 citations
  2. 2Characterization of the anti‐platelet actions of FK419, a novel non‐peptide antagonist of platelet GPIIb/IIIa2004 · 25 citations
  3. 3Platelet Glycoprotein IIb/IIIa Inhibitor Tirofiban Ameliorates Cardiac Reperfusion Injury2015 · 15 citations
  4. 4Tirofiban: an investigational plateletglycoprotein IIb/IIIa receptor antagonist1997 · 18 citations
  5. 5Bleeding Risk of Tirofiban, a Nonpeptide GPIIb/IIIa Platelet Receptor Antagonist in Progressive Stroke: An Open Pilot Study2001 · 74 citations