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February 12, 2002Neurology

The infarct volume (T2 lesion after 1 week) was significantly smaller in tirofiban-treated patients compared with matched control subjects (p = 0.029).

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Why the study?

Does tirofiban reduce infarct volume in patients with acute ischemic stroke?

Population

20 patients with acute ischemic stroke (n=10 treated, n=10 matched controls)

Comparison

Tirofiban (glycoprotein IIb/IIIa antagonist) vs Matched control subjects

Design

Cohort, open

Follow-up

1 week

Authors

UJUlrich JunghansRSRüdiger J. SeitzARAfra Ritzl

Discussion

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Overview

Tirofiban was associated with smaller infarcts; leaves open neuroprotective efficacy in acute ischemic stroke pending randomized trials.

Structured PICO

Does tirofiban reduce infarct volume in patients with acute ischemic stroke?

P
Population
20 patients with acute ischemic stroke (n=10 treated, n=10 matched controls)
I
Intervention
Tirofiban (glycoprotein IIb/IIIa antagonist)
C
Comparator
Matched control subjects
O
Outcome
Infarct volume (T2 lesion after 1 week) as defined by MRIsurrogate

Tirofiban may salvage ischemic brain tissue and reduce infarct volume in patients with acute ischemic stroke.

Cite This Study

Junghans et al. (2002) studied this question.

synapsesocial.com/papers/6a766ea3232067cbf2ec065bhttps://doi.org/10.1212/wnl.58.3.474
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bleeding Risk of Tirofiban, a Nonpeptide GPIIb/IIIa Platelet Receptor Antagonist in Progressive Stroke: An Open Pilot Study2001 · 74 citations
  2. 2Platelet glycoprotein IIb/IIIa antagonists for acute ischemic stroke2001 · 23 citations
  3. 3Safety of Glycoprotein IIb-IIIa Inhibitors Used in Stroke-Related Treatment: A Systematic Review and Meta-Analysis2020 · 30 citations
  4. 4Effect of Tirofiban Therapy on ST Segment Resolution and Clinical Outcomes in Patients with ST Segment Elevated Acute Myocardial Infarction Undergoing Primary Angioplasty2006 · 11 citations
  5. 5Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke2014 · 106 citations