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September 1, 2001Neurology

Platelet glycoprotein IIb/IIIa antagonists for acute ischemic stroke

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Key result

Platelet glycoprotein IIb/IIIa antagonists have potential applications in the treatment of acute ischemic stroke and as adjunctive therapy to carotid angioplasty.

Why the study?

Do platelet glycoprotein IIb/IIIa antagonists improve safety and efficacy compared with standard rt-PA in patients with acute ischemic stroke?

Population

Patients with acute ischemic stroke

Comparison

Platelet glycoprotein IIb/IIIa antagonists… vs Standard recombinant tissue plasminogen activator

Design

Review

Authors

JBJulien BogousslavskyUniversity of GenevaJLJacques R. LeclercEli Lilly (United States)

Discussion

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Implication

May support exploratory roles in acute ischemic stroke; leaves open efficacy versus rt-PA pending randomized trials.

Structured PICO

Do platelet glycoprotein IIb/IIIa antagonists improve safety and efficacy compared with standard rt-PA in patients with acute ischemic stroke?

P
Population
Patients with acute ischemic stroke
I
Intervention
Platelet glycoprotein (GP) IIb/IIIa antagonists, alone or in combination with reduced doses of thrombolytic agents
C
Comparator
Standard recombinant tissue plasminogen activator (rt-PA)

Platelet glycoprotein IIb/IIIa antagonists may have potential applications in the treatment of acute ischemic stroke and as adjunctive therapy to carotid angioplasty.

Cite This Study

Bogousslavsky et al. (2001) conducted a review in acute ischemic stroke. Platelet glycoprotein IIb/IIIa antagonists vs. standard recombinant tissue plasminogen activator (rt-PA) was evaluated. Platelet glycoprotein IIb/IIIa antagonists have potential applications in the treatment of acute ischemic stroke and as adjunctive therapy to carotid angioplasty.

synapsesocial.com/papers/6a99dd851aede4d0e945a7efhttps://doi.org/10.1212/wnl.57.suppl_2.s53

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycoprotein IIb/IIIa receptor antagonists in the management of cardiovascular diseases1998 · 21 citations
  2. 2Epidemiology of Carotid Endarterectomy Among Medicare Beneficiaries1998 · 166 citations
  3. 3Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.1998 · 242 citations
  4. 4The Platelet IIb/IIIa Inhibitor Abciximab as Adjunctive Therapy in Carotid Stenting of Potential Thrombotic Lesions1999 · 17 citations
  5. 5Pharmacodynamic Profile of Short-term Abciximab Treatment Demonstrates Prolonged Platelet Inhibition With Gradual Recovery From GP IIb/IIIa Receptor Blockade1998 · 287 citations