Population
Mice infected with Friend disease virus (FDV)
Design
Preclinical
Authors
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Should not alter clinical management of viral infections; leaves open immunomodulatory effects of sera and silica on retroviral oncogenesis.
In a mouse model of Friend disease, both normal and antithymocyte serum increased susceptibility to infection, while silica potentiated infection depending on the route of viral administration.
Larson et al. (1972) studied this question.
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