The compound 6-(3,4-dichlorophenoxy)-3-(ethylthio)-2-pyridincarbonitrile acts as an antiviral against poliovirus by specifically targeting viral uncoating.
Supports uncoating-targeted antivirals in preclinical models; leaves open translation to human poliovirus therapy.
We investigated the mode of action of 6-(3,4-dichlorophenoxy-3-(ethylthio)-2-pyridincarbonitrile against poliovirus. This agent effectively blocked the synthesis of poliovirus proteins and RNA when it was added at the beginning of infection. Poliovirus attachment and internalization into HeLa cells were not inhibited in the presence of the compound; poliovirus uncoating was the target of its activity.
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González et al. (1990) studied this question.
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