The thiopyrimidine derivative S-7 demonstrates antiviral activity by preventing poliovirus RNA synthesis and protecting host cell protein synthesis.
Hypothesis-generating for poliovirus antivirals; leaves open clinical translation from animal data.
SUMMARY A thiopyrimidine derivative, i.e. ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate (S-7) is capable of preventing both poliovirus RNA synthesis and virus induced inhibition of cell protein synthesis.
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Colla et al. (1972) studied this question.
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