Why the study?
Does melphalan improve congestive heart failure in patients with AL amyloidosis?
Does melphalan improve congestive heart failure in patients with AL amyloidosis?
A small fraction (2.1%) of patients with AL amyloidosis and heart failure experienced marked resolution of disease, which was associated with melphalan treatment and the abolition of light chains.
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Melphalan-associated remission in a small AL amyloidosis subset is hypothesis-generating; should not yet change practice.
Simon W Dubrey (1996) studied this question.
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