Why the study?
Does ADP-induced intravascular platelet aggregation cause pulmonary artery injury in rabbits, and is it prevented by thrombocytopenia or aspirin?
Population
28 male rabbits
Comparison
Adenosine diphosphate 2-5 mg/kg injected into… vs No pretreatment (n=17)
Design
Preclinical
Follow-up
1 hour
Authors
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Hypothesis-generating for platelet-mediated pulmonary vascular injury in models; leaves open human translation and clinical relevance.
Does ADP-induced intravascular platelet aggregation cause pulmonary artery injury in rabbits, and is it prevented by thrombocytopenia or aspirin?
Intravascular platelet aggregation induced by ADP causes pulmonary artery contraction and endothelial injury, which can be prevented by aspirin, suggesting mediation by prostaglandin endoperoxides and thromboxane A2.
Motomiya et al. (1979) studied this question.
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