Key Points
- To examine the relationship between pulmonary functional changes and the platelet release reaction during repeated episodes of induced intravascular platelet aggregation.
- Induced repeated episodes of intravascular platelet aggregation in cats through intravenous infusions of either adenosine diphosphate (ADP) or collagen.
- Measured serial plasma concentrations of platelet factor 4 (PF-4) to evaluate the platelet release reaction alongside changes in pulmonary vascular resistance and dynamic lung compliance.
- Plasma concentrations of PF-4 increased markedly following the initial episode of induced intravascular platelet aggregation.
- Subsequent infusions of ADP or collagen continued to trigger vigorous lung responses despite no further increase in plasma PF-4 concentrations.
Structured PICO
PPopulationCats (feline model)
IInterventionIntravenous infusions of either ADP or collagen to induce repeated episodes of platelet aggregation
OOutcomeLung responses (pulmonary vascular resistance and dynamic lung compliance) and platelet release reaction (plasma concentration of platelet factor 4)surrogate
In a feline model, lung responses to induced platelet aggregation do not correlate with the release of platelet factor 4 after the initial episode.