Key result
Endurance training significantly increased serum levels of irisin (p=0.03) in diabetic rats, with a significant correlation between serum betatrophin and beta-cell function (p=0.03).
Why the study?
Betatrophin is secreted following exercise-induced muscle irisin expression, but the effect of endurance training on serum levels of irisin and betatrophin in diabetes required investigation.
Does endurance training increase serum levels of irisin and betatrophin in streptozotocin-induced diabetic rats?
RCT (n=24)
randomly divided
Does endurance training increase serum levels of irisin and betatrophin in streptozotocin-induced diabetic rats?
p-value: p=0.03
Endurance training increases irisin levels in diabetic rats, which may have implications for betatrophin expression and beta-cell function.
No immediate clinical implications; leaves open irisin and betatrophin as exercise targets for beta-cell function in diabetes.
Betatrophin known as pancreatic β-cell proliferation marker is secreted as a result of the muscle irisin’s expression induced by exercise. The present study aimed to investigate the effect of endurance training on serum levels of irisin and betatrophin in diabetic rats. Twenty-four Wistar rats were randomly divided into three groups of (1) healthy control group (H-CG), (2) diabetic control group (D-CG), and diabetic group submitted to endurance training (D-ETG). The D-ETG performed endurance exercise (4 week/5 days) on the rodent treadmill. For data analysis we used one-way ANOVA, Scheffe test and Pearson correlation coefficient. Irisin (p = .04) and betatrophin (p = .005) levels were significantly decreased in the D-CG. Endurance exercise only increased serum levels of irisin significantly (p = .03). There was a significant correlation was shown between serum betatrophin and beta-cell function (p = .03). It appears that a specific exercise training can increase irisin hormone, with possible impact on betatrophin expression in diabetic individuals.
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Sadeghipour et al. (2020) conducted an RCT in streptozotocin-induced diabetes (n=24). Endurance training vs. Diabetic control group and healthy control group was evaluated on Serum levels of irisin and betatrophin (p=0.03). Endurance training significantly increased serum levels of irisin (p=0.03) in diabetic rats, with a significant correlation between serum betatrophin and beta-cell function (p=0.03).
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