Key result
Thrombus formation on arterial stenoses depends on thrombin generation and shear-induced platelet activation, highlighting the need for miniature diagnostic blood-flow devices.
Population
Human non-anticoagulated blood from healthy individuals and patients with various bleeding disorders
Design
Review
Authors
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May support miniature devices for antithrombotic monitoring in atherosclerosis; leaves open clinical utility pending prospective validation.
Miniature models of high shear stenosis blood-flow devices could be useful for assessing and monitoring the efficacy of antithrombotic regimens in patients with atherosclerotic disease.
Kjell S. Sakaríassen (2007) conducted a review in Thrombus formation on arterial stenoses. Thrombus formation on arterial stenoses depends on thrombin generation and shear-induced platelet activation, highlighting the need for miniature diagnostic blood-flow devices.
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