Key result
Aerobic exercise training increased skeletal muscle microRNA-1 expression by 53% (P=0.02) and decreased PTEN expression, contributing to attenuated skeletal myopathy in patients with HFrEF.
Why the study?
Exercise intolerance in HFrEF is mostly attributed to skeletal muscle alterations, but the underlying mechanisms of skeletal myopathy are not completely understood.
Does aerobic or inspiratory muscle training improve skeletal muscle microRNA-1 expression, functional capacity, and quality of life in patients with HFrEF?
Comparison
AET vs IMT vs control
Design
Randomized controlled trial
Follow-up
4 months
Authors
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AET provides molecular muscle benefits beyond functional gains in HFrEF; extends RCT evidence on microRNA-1 pathways.
RCT (n=33)
randomized into control, IMT, and AET groups
Does aerobic or inspiratory muscle training improve skeletal muscle microRNA-1 expression, functional capacity, and quality of life in patients with HFrEF?
p-value: p=0.02
Aerobic exercise training, but not inspiratory muscle training, upregulates skeletal muscle microRNA-1 and associated pathways, contributing to attenuated skeletal myopathy and improved functional capacity in HFrEF.
Antunes‐Correa et al. (2019) conducted an RCT in chronic heart failure with reduced ejection fraction (HFrEF) (n=33). Aerobic exercise training (AET) and inspiratory muscle training (IMT) vs. control was evaluated on skeletal muscle microRNA-1 expression (p=0.02). Aerobic exercise training increased skeletal muscle microRNA-1 expression by 53% (P=0.02) and decreased PTEN expression, contributing to attenuated skeletal myopathy in patients with HFrEF.
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