Key result
Higher levels of CD4+CD28null T-lymphocytes were significantly associated with cardiovascular mortality in chronic heart failure patients with atrial fibrillation (HR per 1-SD 1.59; 95% CI 1.13-2.24).
Why the study?
Does the fraction of CD4+CD28null T-lymphocytes predict cardiovascular mortality in patients with chronic heart failure and atrial fibrillation?
Population
112 patients with chronic heart failure, stratified into those presenting with atrial fibrillation and those…
Design
Cohort
Follow-up
mean 4.5 years
Authors
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May refine risk stratification in HF-AF; leaves open prospective validation before clinical use.
Cohort (n=112)
Does the fraction of CD4+CD28null T-lymphocytes predict cardiovascular mortality in patients with chronic heart failure and atrial fibrillation?
Hazard Ratio: 1.59 (95% CI 1.13–2.24)
p-value: p=0.008
An increased fraction of CD4+CD28null T-cells is an independent predictor of cardiovascular mortality in patients with chronic heart failure and concomitant atrial fibrillation.
Sulzgruber et al. (2016) conducted a cohort in chronic heart failure (n=112). CD4+CD28null T-lymphocytes was evaluated on cardiovascular mortality (HR 1.59, 95% CI 1.13-2.24, p=0.008). Higher levels of CD4+CD28null T-lymphocytes were significantly associated with cardiovascular mortality in chronic heart failure patients with atrial fibrillation (HR per 1-SD 1.59; 95% CI 1.13-2.24).
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