Key result
Prior CABG in patients with ischemic left ventricular dysfunction was associated with a 25% reduction in risk of death (95% CI, 15% to 36%) and a 46% reduction in sudden death.
Why the study?
Does prior CABG reduce mortality and sudden death in patients with ischemic left ventricular dysfunction?
Population
5,410 patients with ischemic left ventricular dysfunction enrolled in the Studies of Left Ventricular…
Comparison
History of prior coronary artery bypass graft… vs No history of prior CABG surgery
Design
Cohort
Authors
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May explain absent ICD benefit post-CABG; hypothesis-generating for causal mortality effects in ischemic LV dysfunction.
Observational (n=5,410)
Yes
Does prior CABG reduce mortality and sudden death in patients with ischemic left ventricular dysfunction?
Effect estimate: 25% reduction (95% CI 15% to 36%)
In patients with ischemic LV dysfunction, prior CABG is associated with a significant reduction in overall mortality and sudden death, which may explain the lack of benefit from prophylactic defibrillators in post-CABG patients.
Veenhuyzen et al. (2001) conducted an observational in Ischemic left ventricular dysfunction (n=5,410). Prior CABG vs. No history of prior CABG was evaluated on Risk of death (25% reduction, 95% CI 15% to 36%). Prior CABG in patients with ischemic left ventricular dysfunction was associated with a 25% reduction in risk of death (95% CI, 15% to 36%) and a 46% reduction in sudden death.
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