Key result
Among 16 patients with idiopathic acute massive pulmonary thromboembolism, 44% (7 patients) were associated with antipsychotic drug use, including risperidone and conventional phenothiazines.
Why the study?
Are antipsychotic medications such as risperidone and conventional phenothiazines associated with acute massive pulmonary thromboembolism in otherwise healthy patients?
Population
47 Japanese patients with acute massive pulmonary thromboembolism seen in an Emergency Center, including a…
Design
Case_series
Authors
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Antipsychotics may associate with idiopathic massive PE in case series; hypothesis-generating, requires prospective confirmation before any clinical inference.
Observational (n=47)
No
Are antipsychotic medications such as risperidone and conventional phenothiazines associated with acute massive pulmonary thromboembolism in otherwise healthy patients?
Risperidone and conventional phenothiazines may be associated with an increased risk of acute massive pulmonary thromboembolism, potentially due to increased coagulability from 5HT2A receptor affinity.
Kamijo et al. (2002) conducted an observational in Acute massive pulmonary thromboembolism (n=47). Antipsychotic medication (risperidone and conventional phenothiazines) was evaluated on Proportion of idiopathic pulmonary thromboembolism cases associated with antipsychotic drug use. Among 16 patients with idiopathic acute massive pulmonary thromboembolism, 44% (7 patients) were associated with antipsychotic drug use, including risperidone and conventional phenothiazines.
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