Why the study?
Does rat atrial natriuretic factor stimulate progesterone secretion and cGMP accumulation in cultured human granulosa-lutein cells?
Population
Cultured human granulosa-lutein (G-L) cells
Comparison
Rat atrial natriuretic factor at 1 X 10M, alone… vs Controls (untreated cells)
Design
Preclinical
Authors
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Hypothesis-generating for ANF in ovarian steroidogenesis; does not support clinical adoption without further study.
Does rat atrial natriuretic factor stimulate progesterone secretion and cGMP accumulation in cultured human granulosa-lutein cells?
ANF stimulates progesterone secretion and cGMP accumulation in human ovarian granulosa-lutein cells, suggesting a role for ANF in ovarian steroidogenesis via a cGMP-dependent mechanism.
Pandey et al. (1987) studied this question.
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