Population
Percoll-purified mouse and rat Leydig cells
Design
Preclinical
Authors
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Species-specific ANP effects on Leydig steroidogenesis in rodents warrant caution extrapolating to humans; leaves open cGMP signaling relevance for further study.
Atrial natriuretic peptides stimulate steroidogenesis in mouse Leydig cells via cyclic GMP as a second messenger, an effect that is species-specific.
Mukhopadhyay et al. (1986) studied this question.
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