Key result
Angiotensin II blunts the aggregation responses of platelets in mice, likely via a loss of SERT on the platelet plasma membrane and depletion of intracellular serotonin.
Why the study?
Does Angiotensin II infusion alter platelet aggregation and serotonin uptake in mice?
Population
Adult C57BL/6J wild type or SERT knockout (SERT KO) male mice (10-12 weeks old)
Comparison
Angiotensin II infusion via subcutaneous osmotic… vs Isotonic saline infusion via subcutaneous…
Design
Preclinical, Adult C57BL/6J male mice were randomized to receive osmotic…
Follow-up
7 days
Authors
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Does not support altering angiotensin II or ARB therapy; hypothesis-generating for human platelet effects.
Does Angiotensin II infusion alter platelet aggregation and serotonin uptake in mice?
Angiotensin II blunts platelet aggregation by reducing serotonin uptake via the serotonin transporter, an effect that can be reversed by the AT1 receptor blocker valsartan.
Singh et al. (2013) studied Hypertension. Angiotensin II was evaluated on Platelet aggregation response and serotonin (5-HT) uptake. Angiotensin II blunts the aggregation responses of platelets in mice, likely via a loss of SERT on the platelet plasma membrane and depletion of intracellular serotonin.
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