Key result
Angiotensin II-dependent hypertension induced reversible changes in 45 platelet protein spots (>1.5-fold, P<0.01), reflecting enhanced protein degradation.
Why the study?
Does angiotensin II-dependent hypertension alter the platelet proteome in rat models?
Population
cyp1a1ren-2 transgenic rats (n=10) and Fischer 344 rats (n=7)
Comparison
Induction of angiotensin II-dependent hypertension vs Normotensive state
Design
Preclinical
Follow-up
14 days of hypertension and 10 days after normalization
Authors
Loading...
Should not change practice; leaves open reversible platelet proteome shifts as hypothesis-generating biomarkers of recent hypertension exposure.
Does angiotensin II-dependent hypertension alter the platelet proteome in rat models?
Effect estimate: >1.5-fold
p-value: p=<0.01
Angiotensin II-dependent hypertension causes reversible enhanced protein degradation in platelets, suggesting potential for novel biomarkers of recent blood pressure history.
Gebhard et al. (2011) studied Angiotensin II-dependent hypertension (n=17). Angiotensin II-dependent hypertension induction vs. Normotensive state was evaluated on Changes in the platelet proteome (>1.5-fold, p=<0.01). Angiotensin II-dependent hypertension induced reversible changes in 45 platelet protein spots (>1.5-fold, P<0.01), reflecting enhanced protein degradation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: