Key result
In Chinese adults, the BMI and LDL cholesterol relationship was inverted U-shaped in males with a peak at 27.1 kg/m2, while an approximately linear positive association was observed in females.
Why the study?
The relationship between BMI and LDL-C had not been clearly elucidated in middle-aged and older adults.
Population
12,273 participants aged 45 to 75 years from two nationally representative surveys in China
Comparison
Association across BMI levels in males vs females
Design
Cross-sectional analysis of two nationally representative surveys
Authors
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Sex-specific BMI-LDL-C patterns may inform risk stratification; leaves open causality and prospective validation.
Cross-Sectional (n=12,273)
Yes
p-value: p=<0.001
The association between BMI and LDL-C exhibits significant sex differences, presenting as an inverted U-shape in middle-aged and older Chinese men and an approximately linear relationship in women.
Li et al. (2021) conducted a cross-sectional in Dyslipidemia and Obesity (n=12,273). Body mass index (BMI) vs. Different BMI levels was evaluated on Non-linear dose-response relationship between BMI and LDL-C (p=<0.001). In Chinese adults, the BMI and LDL cholesterol relationship was inverted U-shaped in males with a peak at 27.1 kg/m2, while an approximately linear positive association was observed in females.
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