Key result
BMI linked to an inverted U-shaped LDLc curve peaking at ~27 kg/m2.
Why the study?
What is the dose-response relationship between body mass index or waist circumference and LDL cholesterol in the general population?
Population
24,148 participants from representative samples of U.S. and Spanish noninstitutionalized populations.
Design
Cross-sectional
Authors
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Observed inverted-U BMI-LDLc pattern should not alter lipid management; leaves open causal mechanisms and longitudinal validation.
Cross-Sectional (n=24,148)
Yes
What is the dose-response relationship between body mass index or waist circumference and LDL cholesterol in the general population?
Effect estimate: 2.30 and 2.41 mg/dL per kg/m2 increase below inflection point
p-value: p=<0.001
The relationship between BMI and LDL cholesterol follows an inverted U shape, indicating that LDLc rises with BMI only in lean individuals, whereas it declines at higher BMI levels.
Laclaustra et al. (2018) conducted a cross-sectional in Elevated LDL cholesterol (n=24,148). Body mass index (BMI) and waist circumference (WC) was evaluated on Dose-response relationship between BMI or WC and LDLc (2.30 and 2.41 mg/dL per kg/m2 increase below inflection point, p=<0.001). Body mass index and LDL cholesterol have an inverted U-shaped relationship, with LDLc rising by 2.30-2.41 mg/dL per kg/m2 below BMI ~27 kg/m2 and declining above this point (P<0.001).
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