What question did this study set out to answer?

To evaluate the time course of adenine nucleotide breakdown and regional blood flow across transmural myocardial layers during the first hour of acute coronary artery occlusion.

January 1, 1992Scandinavian Journal of Clinical and Laboratory Investigation

Myocardial adenine nucleotide depletion within 1 h of acute coronary artery occlusion

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Population

Anaesthetized open-chest cats

Design

Preclinical

Follow-up

60 minutes

Authors

HBHarald BrunvandCardiac Imaging JWJ. WestbyHaukeland University Hospital JLJ. LekvenUniversity of Bergen

Discussion

Member takes

Implication

Indicates transmural ischemic vulnerability; hypothesis-generating in cats, leaves open human translation.

Key Points

To evaluate the time course of adenine nucleotide breakdown and regional blood flow across transmural myocardial layers during the first hour of acute coronary artery occlusion.
Occluded the left anterior descending coronary artery (LAD) in open-chest anesthetized cats.
Measured tissue blood flow using radioactive microspheres and quantified adenine nucleotides and degradation products (ATP, adenosine, inosine, hypoxanthine, and xanthine) using high-pressure liquid chromatography at 5, 10, 20, 40, and 60 minutes post-occlusion.
Both epicardial and endocardial layers exhibited rapid, parallel ATP depletion and accumulation of adenosine, inosine, hypoxanthine, and xanthine within the first 20 minutes.
At 40 and 60 minutes, ATP loss and catabolite accumulation continued in the endocardium but stabilized in the epicardium, an effect not explained by modest differences in epicardial blood flow on analysis of covariance.
Adenosine levels fell after 40 minutes of ischemia across both myocardial wall layers, declining to negligible levels by 60 minutes.

Structured PICO

Population

Anaesthetized open-chest cats

Intervention

Acute occlusion of the left anterior descending coronary artery (LAD)

Outcome

Myocardial adenine nucleotides (ATP) and degradation products (adenosine, inosine, hypoxanthine, xanthine) and tissue blood flow at 5, 10, 20, 40, and 60 minsurrogate

In a cat model of acute coronary occlusion, the breakdown of energy stores is less severe in epicardial than endocardial layers during the first hour, suggesting transmural heterogeneity in metabolic function during severe ischaemia.

Cite This Study

Brunvand et al. (1992) studied this question.

synapsesocial.com/papers/6a98f9eaee2e02d2bfe109c0 https://doi.org/10.3109/00365519209115505

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Myocardial adenine nucleotide depletion within 1 h of acute coronary artery occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Myocardial adenine nucleotide depletion within 1 h of acute coronary artery occlusion

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider