Key result
Expression of the coxsackievirus and adenovirus receptor (CAR) and its D2 deletion mutant significantly inhibited the tumorigenicity of U-118 MG glioma cells both in vitro and in vivo (P<0.05).
Population
Human U-118 MG glioma cells and 8- to 10-week-old female athymic nude mice (nu/nu)
Comparison
Transfection with wild-type human coxsackievirus… vs Parental U-118 MG cells or cells transfected…
Design
Preclinical
Follow-up
21 days (in vivo), 18 days (in vitro)
Authors
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Supports CAR as tumor suppressor in glioma models; leaves open human translation.
p-value: p=<0.05
The coxsackievirus and adenovirus receptor (CAR) acts as a tumor suppressor in glioma cells, and its extracellular D2 domain is not required for this inhibitory effect.
Kim et al. (2003) studied Malignant glioma. Expression of coxsackievirus and adenovirus receptor (CAR) and its mutants vs. Parental U-118 MG cells or empty vector was evaluated on Tumor volume (in vivo) and colony formation (in vitro) (p=<0.05). Expression of the coxsackievirus and adenovirus receptor (CAR) and its D2 deletion mutant significantly inhibited the tumorigenicity of U-118 MG glioma cells both in vitro and in vivo (P<0.05).
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