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May 23, 2006The FASEB Journal

Aldosterone mediates angiotensin II‐induced interstitial cardiac fibrosis via a Nox2‐containing NADPH oxidase

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Population

Nox2-/- mice and matched wild-type (WT) controls

Comparison

Subcutaneous Angiotensin II or chronic… vs Wild-type controls without intervention, and…

Design

Preclinical

Follow-up

2 weeks

Authors

ACAlison CaveANAnilkumar NarayanapanickerDGDavid Grieve

Discussion

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Overview

Preclinical findings do not support clinical use of Nox2 inhibitors; leaves open translation to human cardiac fibrosis.

Structured PICO

P
Population
Nox2-/- mice and matched wild-type (WT) controls
I
Intervention
Subcutaneous Angiotensin II (1.1 mg/kg/day for 2 weeks) or chronic aldosterone infusion (0.2 mg/kg/day) with a 1% NaCl diet
C
Comparator
Wild-type controls without intervention, and Nox2-/- mice
O
Outcome
Interstitial cardiac fibrosis and NADPH oxidase activitysurrogate

Aldosterone-dependent activation of a Nox2-containing NADPH oxidase is a key mechanism mediating Angiotensin II-induced and mineralocorticoid-dependent interstitial cardiac fibrosis.

Cite This Study

Cave et al. (2006) studied this question.

synapsesocial.com/papers/6a99301b3fce915289052f8ahttps://doi.org/10.1096/fj.05-4642fje
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Also Consider

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