フロセミド長期内服中に短期間の経口摂取不良を契機として発症したウェルニッケ脳症の1例(A case of wernicke encephalopathy triggered by short–term poor oral intake in a patient receiving long–term furosemide therapy)

Q: What does this research mean for the field?

Long-term furosemide therapy can predispose patients to Wernicke encephalopathy following only short-term poor oral intake due to enhanced thiamine excretion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

本郷 葉子; 若竹 春明; Minoru Yoshida; 田上 ひとみ; 中薗 健一; Yuka Kitano; Yoshihiro Masui

doi:10.1002/jja2.13174

September 1, 2026Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute MedicineOpen Access

フロセミド長期内服中に短期間の経口摂取不良を契機として発症したウェルニッケ脳症の1例(A case of wernicke encephalopathy triggered by short–term poor oral intake in a patient receiving long–term furosemide therapy)

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Key Points

To describe a case of Wernicke encephalopathy triggered by brief poor oral intake in a patient on long-term furosemide therapy without alcohol use disorder.
Clinical evaluation and management of a single patient on long-term furosemide therapy who experienced acute neurological deterioration following three days of reduced oral intake.
The patient developed Wernicke encephalopathy after only three days of inadequate oral intake despite lacking classic risk factors such as chronic alcohol abuse or prolonged starvation.
Chronic furosemide administration likely accelerated urinary excretion of thiamine (vitamin B1), depleting systemic reserves and predisposing the patient to rapid neurotoxicity.

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Implication

Case report demonstrates acute Wernicke encephalopathy after brief fasting in a patient taking chronic furosemide, highlighting diuretic-induced thiamine loss.

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葉子 et al. (2026) studied this question.

synapsesocial.com/papers/6a99351f636c6408cfa7d09f https://doi.org/10.1002/jja2.13174

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フロセミド長期内服中に短期間の経口摂取不良を契機として発症したウェルニッケ脳症の1例(A case of wernicke encephalopathy triggered by short–term poor oral intake in a patient receiving long–term furosemide therapy)

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フロセミド長期内服中に短期間の経口摂取不良を契機として発症したウェルニッケ脳症の1例(A case of wernicke encephalopathy triggered by short–term poor oral intake in a patient receiving long–term furosemide therapy)

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