What is the clinical evidence from this study?

Study design: Cohort. Population: Obesity (n=40). Intervention: Bariatric surgery vs. Baseline (before surgery). Primary outcome: Fasting insulin (mU/L) (p=<0.001).

March 1, 2019Diabetes and Vascular Disease ResearchOpen Access

Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6

Q: What are the key findings of this study?

Bariatric surgery significantly reduced fasting insulin from 21.3 to 7.8 mU/L and insulin resistance from 5.9 to 1.8 at 1 year (all p<0.001).

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Key result

Bariatric surgery significantly reduced fasting insulin from 21.3 to 7.8 mU/L and insulin resistance from 5.9 to 1.8 at 1 year (all p<0.001).

Why the study?

To study the effect of bariatric surgery on small, dense low-density lipoprotein and other atherosclerosis risk factors clustered in the Reaven hypothesis.

Does bariatric surgery improve insulin resistance, small dense LDL, and interleukin-6 levels in patients undergoing the procedure?

Comparison

Before vs 1 year after bariatric surgery

Follow-up

1 year

Authors

SASafwaan AdamManchester Academic Health Science Centre YLYifen LiuUniversity of Manchester TSTarza SiahmansurUniversity of Manchester

Discussion

Member takes

Implication

Associated metabolic improvements after bariatric surgery support further study; leaves open effects on cardiovascular outcomes.

Study Design

Type

Cohort (n=40)

Structured PICO

Does bariatric surgery improve insulin resistance, small dense LDL, and interleukin-6 levels in patients undergoing the procedure?

Population

40 patients (20 with type 2 diabetes mellitus) undergoing bariatric surgery, followed for 1 year.

Exposure

Bariatric surgery

Comparator

Baseline (pre-surgery)

Outcome

Changes in fasting insulin, insulin resistance (HOMA-IR), highly sensitive C-reactive protein, interleukin-6, fasting triglycerides, small, dense low-density lipoprotein, and high-density lipoprotein cholesterol at 1 yearsurrogate

Main Result

Absolute Event Rate: 7.8% vs 21.3%

p-value: p=<0.001

Bariatric surgery significantly reduces insulin resistance, small dense LDL, and inflammatory markers at 1 year, providing a model for understanding the link between hyperinsulinemia and atherosclerosis.

Cite This Study

Adam et al. (2019) conducted a cohort in Obesity (n=40). Bariatric surgery vs. Baseline (before surgery) was evaluated on Fasting insulin (mU/L) (p=<0.001). Bariatric surgery significantly reduced fasting insulin from 21.3 to 7.8 mU/L and insulin resistance from 5.9 to 1.8 at 1 year (all p<0.001).

synapsesocial.com/papers/6a993efb4f4bbec9e275cbec https://doi.org/10.1177/1479164119826479

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Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Bariatric surgery as a model to explore the basis and consequences of the Reaven hypothesis: Small, dense low-density lipoprotein and interleukin-6

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider