Key result
Nitrendipine 10 mg daily for one week reduced resting blood pressure and improved exercise hemodynamics without decreasing cardiac function in patients with effort angina and old myocardial infarction.
Why the study?
Does nitrendipine improve hemodynamics during exercise in patients with effort angina pectoris and old myocardial infarction?
Does nitrendipine improve hemodynamics during exercise in patients with effort angina pectoris and old myocardial infarction?
Nitrendipine exerts antianginal effects and reduces afterload without depressing cardiac function during exercise in patients with effort angina and prior myocardial infarction.
Supports cautious use of nitrendipine in effort angina with old MI; leaves open confirmation of clinical outcomes in randomized trials.
Nitrendipine is a dihydropyridine calcium entry blocker. The effect of nitrendipine on hemodynamics at rest and during exercise with a supine bicycle ergometer with multistage protocol was studied in 10 cases of effort angina pectoris with old myocardial infarction.Nitrendipine was given orally at a daily dose of 10 mg for one week and various hemodynamic parameters were measured at rest and during exercise before and after the treatment with nitrendipine. At rest, the blood pressure was reduced, total peripheral resistance and pulmonary artery pressure tended to decrease, heart rate, cardiac index and stroke index were unchanged, and left ventricular ejection fraction tended to increase.At peak exercise, the blood pressure tended to decrease, heart rate, cardiac index and stroke index tended to increase, the rise in pulmonary artery pressure was suppressed, the pulmonary vascular resistance decreased, and the decrease in the left ventricular ejec tion fraction was reduced.It is concluded that nitrendipine exerts antianginal action without decreasing cardiac function.
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Saito et al. (1989) studied Effort angina pectoris with old myocardial infarction (n=10). Nitrendipine vs. Baseline (before treatment) was evaluated on Resting systolic blood pressure (mmHg). Nitrendipine 10 mg daily for one week reduced resting blood pressure and improved exercise hemodynamics without decreasing cardiac function in patients with effort angina and old myocardial infarction.
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